Search on: IMMUNOGLOBULIN J-CHAINS 
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Descriptor English:   Immunoglobulin J-Chains 
Descriptor Spanish:   Cadenas J de Inmunoglobulina 
Descriptor Portuguese:   Cadeias J de Imunoglobulina 
Synonyms English:   Chains, Ig J
Ig J Chains
Ig J Peptide
Ig J-Peptide
Immunoglobulin J Chains
Immunoglobulin J Peptide
Immunoglobulin J Polypeptide
Immunoglobulin J-Peptide
J Chains, Ig
J Chains, Immunoglobulin
J Polypeptide, Immunoglobulin
J-Chains, Immunoglobulin
J-Peptide, Ig
J-Peptide, Immunoglobulin
Polypeptide, Immunoglobulin J  
Tree Number:   D12.776.124.486.485.705.625
D12.776.124.790.651.705.625
D12.776.377.715.548.705.625
Definition English:   A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains. 
Pharmacological Action:   Immunologic Factors
 
See Related English:   Immunoglobulin A
Immunoglobulin M
 
History Note English:   2006 (1974) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PD pharmacology
PH physiology PO poisoning
RE radiation effects TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30363 
Unique Identifier:   D007144 

Occurrence in VHL: 		 

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